The COVID-19 pandemic had adverse impacts across a broad range of industries except for healthcare and Pharmaceuticals. It has changed the business dynamics globally. Despite all odds, to our surprise, in the course of our primary survey to study the impact of COVID-19 on Indian micro, small and medium enterprises (MSMEs), we came across about four enterprises, one in the engineering sector and the other three in chemical dyes-related industries, that could sail through the tough period with certain managerial, technical, entrepreneurial strategies and structural advantages, without any significant adverse impact on their businesses. This paper presents the resilience of these enterprises during the period of the COVID-19 pandemic, as case lets. Based on the analysis provides insights into distinct factors that provided them a shield during the crisis, contrary to many other enterprises that suffered extensively. Key characteristics observed were the development of niche products/services with extensive research, entrepreneurs’ technical prowess, and early adaptation to automation leading to increased operational efficiency, and decreased labour dependency, and meticulous financial management. The paper discusses in detail the key strategies adopted by these survivors.