In this article, we introduce the topological folding of some operations in a special family of knots and their homology groups. We obtain the relationship between the topological folding in the homology group of knots and their subgroups. We deduce the homology group of the end limits resulting from iterative topological foldings on the n-dimensional knot. We discuss the We discuss the limit unfolding that involves varying curvature and torsion, which are related to the homology group of the unknot. We present some applications in biochemistry.