<?xml version="1.0" encoding="UTF-8"?>
<article article-type="Research Article">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">journal-of-interdisciplinary-mathematics</journal-id>
      <journal-title-group>
        <journal-title>Journal of Interdisciplinary Mathematics</journal-title>
      </journal-title-group>
      <issn publication-format="electronic">2169-012X</issn>
      <issn publication-format="print">0972-0502</issn>
      <publisher>
        <publisher-name>Taru Publications</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.47974/JIM-2836</article-id>
      <title-group>
        <article-title>Mathematical modeling of biological systems using differential equations</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Kakade</surname>
            <given-names>Satish V.</given-names>
          </name>
          <aff>Department of Community Medicine, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, 415539, India</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mishra</surname>
            <given-names>Rahul</given-names>
          </name>
          <aff>Department of Computer Science and Engineering, Rungta College of Engineering &amp; Technology, Rungta International Skills University, Bhilai, Chhattisgarh, 490024, India</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Chaudhary</surname>
            <given-names>Swapnil</given-names>
          </name>
          <aff>Department of Mathematics, Indira College of Engineering and Management, Pune, Maharashtra, 410506, India</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Savithri</surname>
            <given-names>H.</given-names>
          </name>
          <aff>Department of Mathematics, Dayananda Sagar College of Engineering, Bangalore, Karnataka, 560111, India</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Taneja</surname>
            <given-names>Madhur</given-names>
          </name>
          <aff>Centre for Research Impact and Outcome (CRIO), Chitkara University, Rajpura, Punjab, 140401, India</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Babu</surname>
            <given-names>Makineedi Raja</given-names>
          </name>
          <aff>Department of Information Technology, Aditya University, Surampalem, Andhra Pradesh, 533437, India</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Naidu Pamuluri</surname>
            <given-names>Vinod Kumar</given-names>
          </name>
          <aff>Department of Mechanical Engineering, Pragati Engineering College, Surampalem, Andhra Pradesh, 533437, India</aff>
        </contrib>
      </contrib-group>
      <volume>29</volume>
      <issue>10</issue>
      <fpage>2945</fpage>
      <lpage>2956</lpage>
      <pub-date date-type="pub">
        <day>27</day>
        <month>10</month>
        <year>2026</year>
      </pub-date>
      <abstract>
        <p>Nonlinear interactions and temporal evolution in a biological system can be mathematically modeled by differential equations and can be analysed quantitatively. Combining biologically relevant growth, mortality, resource limitation, interaction, regulation, equilibrium, stability and numerical solution mechanisms, this study suggests an integrated framework. The novelty is to combine the three elements of nonlinear biological dynamics, Jacobian-based stability assessment, and comparative numerical evaluation, in a coherent modeling framework. The Euler, Heun, Midpoint, third-order Runge–Kutta (RK3) and fourth-order Runge–Kutta (RK4) methods were compared at a step size of 0.10. The results show that RK4 gives the highest accuracy of 98.8%, with the lowest RMSE of 0.012, and the lowest absolute error of 0.009 when compared to Euler with 91.6% accuracy and RMSE of 0.084. RK3 achieved 97.5% accuracy with 0.025 RMSE. These results confirm numerical reliability for studying nonlinear dynamics, equilibrium behavior, stability and responses of systems as a function of their parameters.</p>
      </abstract>
      <kwd-group>
        <kwd>Biological systems</kwd>
        <kwd>Differential equations</kwd>
        <kwd>Mathematical modeling</kwd>
        <kwd>Stability analysis</kwd>
        <kwd>Numerical simulation</kwd>
        <kwd>Dynamical systems</kwd>
      </kwd-group>
      <custom-meta-group>
        <custom-meta>
          <meta-name>access</meta-name>
          <meta-value>open</meta-value>
        </custom-meta>
        <custom-meta>
          <meta-name>retracted</meta-name>
          <meta-value>no</meta-value>
        </custom-meta>
      </custom-meta-group>
    </article-meta>
  </front>
</article>
