The 4th International Conference on Information Management & Machine Intelligence was held at Poornima Institute of Engineering and Technology, Jaipur on 23-24 December 2022. We are pleased to present this special issue on “Mathematical Modelling for Intelligent and Smart Systems” (containing the papers presented at the conference), which aspires to showcase the research and advancements in the development of mathematical modelling techniques in various domains. Mathematical modelling has become an essential activity in the study of simulating physical phenomena through computational processes, enabling us to predict the behaviour of artifacts within their environments. In recent years, machine learning (ML) and artificial intelligence (AI) have emerged as powerful tools in data science and decision-making processes. Mathematical approaches, such as ML, have proven instrumental in developing concise decision models, producing quick approximations, and forecasting changing phenomena based on known samples. The integration of mathematical modelling and machine learning has significantly improved machine intelligence and its applicability in diverse domains.