Topological indices serve as molecular structure descriptors that characterize the topology of a molecule while remaining invariant under graph isomorphism. Discrete Adriatic indices, explored by Vukičević and Gašperov in 2010, are a significant category of topological indices that have demonstrated strong predictive capabilities in assessments implemented by the International Academy of Mathematical Chemistry. Some of the most effective discrete Adriatic indices include the max-min sdeg index, misbalance indeg index, symmetric division deg index, and variable sum exdeg index, all of which have been proposed as potentially useful measures with better quality compared to some existing measures. This paper aims to explore these descriptors for several infinite families of porphyrin-based dendrimers using the edge partition technique.