Mobile agents are powerful advanced technology for distributing computing with intelligent and autonomous execution of assigned tasks. During the execution, mobile agent utilizes a specific life cycle in malicious environment. Collaboration of mobile agents for securing medical data like patient data, patient medical report etc. play important role. In the digital world, smart health care system is required. For secure transfer of patient information from one hospital to another hospital a framework is proposed based on variable threshold Chinese remainder theorem with present and pride lightweight cipher. Chinese remainder theorem is used for secret sharing of key among hospitals. The VT-CRT technique dynamically modifies the threshold in response to system variables, improving adaptability and security while minimizing computing cost. Present and pride are used for encryption and decryption of electronic medical records. This is the collaborative approach of mobile agents for creation and recreation of secret keys among hospitals for authentication. The effectiveness of the healthcare system is determined by the ability to share medical information safely and effectively. The lightweight PRIDE and PRESENT encryption methods provide efficient and low-latency encryption that is ideal for limited resources medical devices. The framework is compared to popular cryptographic systems like AES, DES, and Blowfish in terms of time complexity, communication cost, flexibility, and memory usage. Investigational findings show that the proposed framework enhances security while maintaining optimal speed, making it a reliable solution for safe patient’s information sharing in medical applications.