The growing incorporation of medical sensor networks into healthcare systems has emphasized the crucial requirement for secure and energy-efficient authentication protocols. The purpose of this study is to present a new method called Sidechain-based Trusted Platform Module (s-TPM) authentication, which aims to overcome the inherent difficulties in ensuring the security of medical sensor networks. This study performs a thorough comparison of s-TPM with two well-established authentication protocols, LEAP and TinySec, across multiple evaluation parameters, such as security, energy efficiency, and performance. The s-TPM authentication method utilizes sidechain technology to strengthen the resilience of authentication procedures in medical sensor networks. s-TPM utilizes a decentralized and tamper-proof system to reduce security weaknesses, offering a robust protection against unauthorized entry and data breaches. The results indicate that s-TPM surpasses LEAP and TinySec in terms of security resilience, guaranteeing a dependable protection against diverse cyber threats. Moreover, s-TPM demonstrates exceptional energy efficiency, which enhances the longevity of medical sensor devices’ operation while upholding a high standard of security. The results emphasize the importance of utilizing innovative methods, like s-TPM, to create authentication protocols that are specifically designed for the distinct difficulties encountered in medical settings.